Dr. Atif Ali Khan Khalil

Incharge/Assistant Professor,
Department of Pharmacognosy
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Profile
Publications

Qualifications

Postdoctorate Pharmacognosy (2019-2020), College of Pharmacy, Gyeongsang National University.

PhD Pharmacognosy (2016-2019), College of Pharmacy, Gyeongsang National University.

MS Pharmacognosy (2014-2016), College of Pharmacy, Gyeongsang National University.
Pharm-D (2005-2010), Faculty of Pharmacy, Federal Urdu University

Intermediate (2003-2005), BISE Peshawar

Matriculation (2001-2003), BISE Peshawar

Experience

Aug 2022 – Till date	Assistant Professor Department of Pharmacognosy Lahore College for Women University, Lahore, Pakistan
Feb 2020 – Aug 2022	Assistant Professor Department of Biological Sciences National University of Medical Sciences, Rawalpindi, Pakistan
Sept 2019 –February 2020	Post-Doctoral (Senior Researcher) Gyeongsang National University 501 Jinju daero, Jinju, Gyeongnam 52828, Republic of Korea
March 2016 –August 2019	Research fellow (Ph.D) Gyeongsang National University 501 Jinju daero, Jinju, Gyeongnam 52828, Republic of Korea
July 2011 – Feb. 2014	Hospital Pharmacist Rehman Medical Institute 5/B-2 Phase-5 hayatabad Peshawar Pakistan

Memberships

Opted Member of Board of Studies (BOS) Institute of Pharmacy, LCWU
Invited Member of Academic Council, LCWU
Member of Board of Studies (BOS) Department of Pharmacy, GC University, Faisalabad
Korean Society of Pharmacognosy
Japanese Society of Pharmacognosy

Supervision of Students

Year	Student Name	Thesis Title	Program
2021-2022	Karishma	Antibacterial activities of stilbenes against staphylococcus Aureus	MS
2021-2022	Aniqa Atta	Effects of 2-Methoxy-6-Acetyl-7-Methyl juglone (MAM) on iNOS/NO and H2O2dependent activation of Bax and Bak and its mediated apoptosis in malignant glioma cell lines	MS
2021-2022	Muhammad Rahman	Effects of 2-methoxy- 6-acetyl-7-methyljuglone (MAM) on the expression of GSS, JNK and iNOS genes in human gliomas.	MS
2021-2022	Mudassir Jamil	Green synthesis and characterization of silver nanoparticles using Reynoutria japonica extract: anticancer activities	MS
2021-2022	Falak Niaz	In Vitro Antimicrobial Screening of Juglone Derivatives of Reynoutria Japonica against Enterococcus faecalis	MS
2021-2022	Iqra Anum	Antibacterial activity of Anthraquinones extracted from Reynoutria japonica on Staphylococcus aureus	MS

Book Chapter

Riasat I, Naeem M, Khalil, A.A.K. Polymer for Biomedical Applications. Book Chapter, Springer

Patent

Ahn, M-,J.; Sung, P.W.; Kim, H.J.: Khalil, A.A.K.; Anti-Helicobacter pylori composition comprising 2- alkoxy-6-acetyl-7-methyljuglone as an effective component.

AWARD AND HONORS

▪ Aug. 2019 17^thYoung Pioneer Research Award for outstanding research performance (Gyeongsang National University, Republic of Korea)

▪ Nov. 2018 Best Poster Award (The 49^th Annual Meeting of the Korean Society of Pharmacognosy, Seoul, Republic of Korea)

Administrative Achievement

Started MPhil in Pharmacognosy at LCWU

ABSTRACTS, PRELIMINARY, AND MISCELLANEOUS REPORTS

Oral Presentations:

Khalil, A.A.K. Antimicrobial activities of juglone derivatives extracted from Reynoutria

japonica against Enterococcus faecalis. GNUP International Symposium, Jinju, Republic of

Korea, January 26, 2022.

Khalil, A.A.K. Secondary Metabolites from Reynoutra japonica. One Day Seminar, Zia Uddin Universty, Karachi, Pakistan, February 19, 2022.

Poster Presentations:

Khalil, A.A.K.; Park, W.S; Kim, HJ.; Ahn, M-,J. Anti-Helicobacter pylori compounds from Polygonum cuspidatum. The 47th Annual Meeting of the Korean Society.of

Pharmacognosy, Seoul, Republic of Korea, 2015.

Khalil, A.A.K.; Park, W.S.; Kim, HJ.; Ahn, M-J. Anti-Helicobacter pylori activity of juglone derivatives isolated from Reynoutria japonica. The 49th Annual Meeting of the Korean Society.of Pharmacognosy, Seoul, Republic of Korea,

Research Publications

Khalil, A.A.K., Park, W.S., Kim, H.J., Akter, K.M. and Ahn, M.J., 2016. Anti-Helicobacter pylori compounds from Polygonum cuspidatum. Natural Product Sciences, 22(3), pp.220-224.
Akter, K.M., Kim, H.J., Khalil, A.A.K., Park, W.S., Lee, M.K., Park, J.H. and Ahn, M.J., 2018. Inner morphological and chemical differentiation of Boehmeria species. Journal of natural medicines, 72(2), pp.409-423.
Khan, I., Chowdhury, M.M.R., Song, S.H., Mesalam, A., Zhang, S., Khalil, A.A.K., Jung, E.H., Kim, J.B., Jafri, L., Mirza, B. and Kong, I.K., 2018. Lupeol supplementation improves the developmental competence of bovine embryos in vitro. Theriogenology, 107, pp.203-210.
Khalil, A.A.K., Park, W.S., Lee, J., Kim, H.J., Akter, K.M., Goo, Y.M., Bae, J.Y., Chun, M.S., Kim, J.H.
and Ahn, M.J., 2019. A new anti-Helicobacter pylori juglone from Reynoutria japonica. Archives of pharmacal research, 42(6), pp.505-511.
Al Kury, L.T., Zeb, A., Abidin, Z.U., Irshad, N., Malik, I., Alvi, A.M., Khalil, A.A.K., Ahmad, S., Faheem, M., Khan, A.U. and Shah, F.A., 2019. Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach. Drug design, development and therapy, 13, p.2715.
Kim, J.H., Khalil, A.A.K., Kim, H.J., Kim, S.E. and Ahn, M.J., 2019. 2-Methoxy-7-acetonyljuglone isolated from Reynoutria japonica increases the activity of nuclear factor erythroid 2-Related factor-2 through inhibition of ubiquitin degradation in HeLa cells. Antioxidants, 8(9), p.398.
Park, W.S., Kim, H.J., Choe, S.J., Khalil, A.A.K., Akter, K.M., Shin, M.C., Chung, H.J., Park,
J.H. and Ahn, M.J., 2020. Anatomical characterization and LC-MS profiling of Adenophora roots from Korea. Revista Brasileira de Farmacognosia, 29, pp.695-701.
Al Kury, L.T., Dayyan, F., Ali Shah, F., Malik, Z., Khalil, A.A.K., Alattar, A., Alshaman, R., Ali, A. and Khan, Z., 2020. Ginkgo biloba extract protects against methotrexate-induced hepatotoxicity: a computational and pharmacological approach. Molecules, 25(11), p.2540.
Akter, K.M., Kim, H.J., Park, W.S., Khalil, A.A.K. and Ahn, M.J., 2020. Anti-Helicobacter pylori activity of compounds isolated from Fraxinus mandshurica bark. Natural Product Sciences, 26(2), pp.158-164.
Rahman, Z.U., Al Kury, L.T., Alattar, A., Tan, Z., Alshaman, R., Malik, I., Badshah, H., Uddin, Z., Khalil, A.A.K., Muhammad, N. and Khan, S., 2020. Carveol a naturally-derived potent and emerging nrf2 activator protects against acetaminophen-induced hepatotoxicity. Frontiers in Pharmacology, 11.
Khalil, A.A.K., Akter, K.M., Kim, H.J., Park, W.S., Kang, D.M., Koo, K.A. and Ahn, M.J., 2020. Comparative inner morphological and chemical studies on Reynoutria species in Korea. Plants, 9(2), p.222.
Akter, K.M., Park, W.S., Kim, H.J., Khalil, A.A.K. and Ahn, M.J., 2020. Comparative Studies of Fraxinus Species from Korea Using Microscopic Characterization, Phytochemical Analysis, and Anti-Lipase Enzyme Activity. Plants, 9(4), p.534.
Nasir, A., Khan, M., Rehman, Z., Khalil, A.A.K., Farman, S., Begum, N., Irfan, M., Sajjad, W. and Parveen, Z., 2020. Evaluation of Alpha-Amylase Inhibitory, Antioxidant, and Antimicrobial Potential and Phytochemical Contents of Polygonum hydropiper L. Plants, 9(7), p.852.
Nazir, N., Khalil, A.A.K., Nisar, M., Zahoor, M. and Ahmad, S., 2020. HPLC-UV characterization, anticholinesterase, and free radical-scavenging activities of Rosa moschata Herrm. leaves and fruits methanolic extracts. Brazilian Journal of Botany, 43(3), pp.523-530.
Khan, A., Muhamad, N.A., Ismail, H., Nasir, A., Khalil, A.A.K., Anwar, Y., Khan, Z., Ali, A., Taha, R.M., Al-Shara, B. and Latif, S., 2020. Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice. Plants, 9(11), p.1414.
Haider, A., Faheem, M., Jamal, S.B., Naeem, M., Khalil, A.A.K. and Khan, R., 2020. The Pathophysiology of Repurposed Antiviral Drugs for treatment of COVID-19 Infection. Life and Science, 1(supplement), pp.6-6.
Qazi, A.S., Akhtar, N., Khalil, A.A.K., Ahmed, M.S. and Mumtaz, S., 2020. A Possible Role of Medicinal Plants in finding a Cure for Covid-19. Life and Science, 1(supplement), pp.5-5.
Subhan, F., Khalil, A.A.K., Zeeshan, M., Haider, A., Tauseef, I., Haleem, S.K. and Ibrahim, A.S., 2020. Curcumin: From Ancient Spice to Modern Anti-Viral Drug in COVID-19 Pandemic. Life and Science, 1(supplement), pp.5-5.
Mesalam, A.A., El-Sheikh, M., Joo, M.D., Khalil, A.A.K., Mesalam, A., Ahn, M.J. and Kong, I.K., 2021. Induction of oxidative stress and mitochondrial dysfunction by juglone affects the development of bovine oocytes. International Journal of Molecular Sciences, 22(1), p.168.
Nazir, N., Rahman, A., Uddin, F., Khalil, A.A.K, Zahoor, M., Nisar, M., Ullah, S., Ullah, R., Ezzeldin, E. and Mostafa, G.A., 2021. Quantitative Ethnomedicinal Status and Phytochemical Analysis of Berberis lyceum Royle. Agronomy, 11(1), p.130.
Nasir, A., Khalil, A.A.K., Bhatti, M.Z., Rehman, A.U., Li, J. and Parveen, Z., 2021. Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: Persicaria hydropiper (Smartweed). Current Topics in Medicinal Chemistry.
Khalil, A.A.K., Treatment of irritable bowel syndrome with multi-herbal formula: A case report.
Ilahi, I., Khuda, F., Sahibzada, M.U.K., Alghamdi, S., Ullah, R., Dablool, A.S., Alam, M., Khan,and Khalil, A.A.K., 2021. Synthesis of silver nanoparticles using root extract of Duchesnea indica and assessment of its biological activities. Arabian Journal of Chemistry, 14(5), p.103110.

Begum, N., Nasir, A., Parveen, Z., Muhammad, T., Ahmed, A., Farman, S., Jamila, N., Shah, M., Bibi, N.S., Khurshid, A. Khalil, A.A.K and Huma, Z., 2021. Evaluation of the Hypoglycemic Activity of Morchella conica by Targeting Protein Tyrosine Phosphatase 1B. Frontiers in pharmacology, 12, p.1148.
Shams, S., Imran, N., Afridi, S.G., Ayaz, M., Khalil, A.A.K. and Nasir, A., 2021. In vitro differentiation effect of CCL4-induced liver injured mice serum on bone marrow-derived mesenchymal stem cells toward hepatocytes like cells. Cell and Tissue Banking, 22(2), pp.297- 303.
Nasir, A., Khan, A., Li, J., Naeem, M., Khalil, A.A.K, K. and Qasim, M., 2021. Nanotechnology, A Tool for Diagnostics and Treatment of Cancer. Current Topics in Medicinal Chemistry, 21(15), pp.1360-1376.
Khalil, A.A.K., Qazi, A.S., Nasir, A., Ahn, M.J., Shah, M.A., Ahmad, M.S., Sajjad, W., Ali, T., Naeem, M., Shah, F.A. and Khan, M.T.A., 2021. 2-Methoxy-6-Acetyl-7-Methyljuglone: A Bioactive Phytochemical with Potential Pharmacological Activities. Anti-cancer Agents in Medicinal Chemistry.
Kausar, F., Farooqi, M.A., Farooqi, H.M.U., Salih, A.R.C., Khalil, A.A.K., Kang, C.W., Mahmoud, M.H., Batiha, G.E.S., Choi, K.H. and Mumtaz, A.S., 2021. Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled. Life, 11(7), p.656.
Riasat, I., Bakhtiar, S.M., Faheem, M., Jaiswal, A.K., Naeem, M., Khan, R., Khan, A.U., Khalil, A.A.K., Haider, A., Junaid, M. and de Castro Soares, S., 2021. Application of pan genomics towards the druggability of Clostridium botulinum. Applied Nanoscience, pp.1-13.
Khan, J., Majid, A., Nazir, N., Nisar, M., Khalil, A.A.K, Zahoor, M., Ihsan, M., Ullah, R., Bari, A. and Shah, A.B., 2021. HPLC Characterization of Phytochemicals and Antioxidant Potential of Alnus nitida (Spach) Endl. Horticulturae, 7(8), p.232.
Ali, A., Khalil, A.A.K., Khuda, F., Nazir, N., Ullah, R., Bari, A., Haider, A., Jamal, S.B., Ahmad, S., Khan, Z. and Shah, S.M.M., 2021. Phytochemical and Biological Screening of Leaf, Bark and Fruit Extracts from Ilex dipyrena Wall. Life, 11(8), p.837.
Oshi, M.A., Haider, A., Siddique, M.I., Zeb, A., Jamal, S.B., Khalil, A.A.K. and Naeem, M., 2021. Nanomaterials for chronic inflammatory diseases: the current status and future prospects. Applied Nanoscience, pp.1-14.
Ahmad, B., Ilahi, I., Yousafzai, A.M., Attaullah, M., Rahim, A., Naz, D., Hazrat, A., Batiha, G., Nassan, M.A. and Khalil, A.A.K., 2021. Protective effects of Zizyphus oxyphyla on liver and kidney related serum biomarkers in (CCl 4) intoxicate rabbits. Brazilian Journal of Biology, 83.
Abidin, S.Z.U., Munem, A., Khan, R., Batiha, G.E.S., Amhad, M., Zafar, M., Khalil, A.A.K., Hetta, H.F., Mahmoud, M.H., Sami, A. and Bhatti, M.Z., 2021. Ethnoveterinary botanical survey of medicinal plants used in Pashto, Punjabi and Saraiki communities of Southwest Pakistan. Veterinary Medicine and Science, 7(5), pp.2068-2085.
Ihsan, M., Nazir, N., Ghafoor, A., Khalil, A.A.K., Zahoor, M., Nisar, M., Khames, A., Ullah, R. and Shah, A.B., 2021. Genetic Diversity in Local and Exotic Avena sativa L.(Oat) Germplasm Using Multivariate Analysis. Agronomy, 11(9), p.1713.
Khan, A., Aslam, F., Kanwal, T., Shah, M.R., Khalil, A.A.K., Shah, S.W.A., Alshammari, E.M., El-Masry, E.A., Batiha, G.E.S. and Baty, R.S., 2021. Enhanced Antibacterial Potential of Amoxicillin against Helicobacter pylori Mediated by Lactobionic Acid Coated Zn- MOFs. Antibiotics, 10(9), p.1071.
Khuda, F., Haq, Z.U., Ilahi, I., Ullah, R., Khan, A., Fouad, H., Khalil, A.A.K., Ullah, Z., Sahibzada, M.U.K., Shah, Y. and Abbas, M., 2021. Synthesis of gold nanoparticles using Sambucus wightiana extract and investigation of its antimicrobial, anti-inflammatory, antioxidant and analgesic activities. Arabian Journal of Chemistry, 14(10), p.103343.
Ihsan, M., Nisar, M., Nazir, N., Zahoor, M., Khalil, A.A.K., Ghafoor, A., Khan, A., Mothana, R.A., Ullah, R. and Ahmad, N., 2021. Genetic diversity in nutritional composition of oat (Avena sativa L.) germplasm reported from Pakistan. Saudi Journal of Biological Sciences.
Ali, A., Nasir, A., Shah, S.W.A., Khalil, A.A.K., Ahn, M.J., Shah, S.M.M., Subhan, F., Faheem, M., Sajjad, W., Shoaib, M. and Ahmad, S., 2021. Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice. BMC Complementary Medicine and Therapies, 21(1), pp.1-11.
Park, W.S., Kim, H.J., Khalil, A.A.K., Kang, D.M., Akter, K.M., Kwon, J.M., Kim, Y.U., Piao, X.L., Koo, K.A. and Ahn, M.J., 2021. Anatomical and Chemical Characterization of Ulmus Species from South Korea. Plants, 10(12), p.2617.
Kausar, F., Kim, K.H., Farooqi, H.M.U., Farooqi, M.A., Kaleem, M., Waqar, R., Khalil, A.A.K., Khuda, F., Abdul Rahim, C.S., Hyun, K. and Choi, K.H., 2022. Evaluation of Antimicrobial and Anticancer Activities of Selected Medicinal Plants of Himalayas, Pakistan. Plants, 11(1), p.48.
Ahmad, B., Yousafzai, A.M., Khan, W., Rahman, H.U., Almehmadi, M., Halawi, M., Alghamdi, S., Khalil, A.A.K. and Khuda, F., 2022. Evaluation of in-vitro and in-vivo antimicrobial potential of Typha elephantina leaves extracts using Cyprinus carpio as a research model. Pak. J. Pharm. Sci, 35(1), pp.323-333.
Farooqi, H.M.U., Sammantasinghar, A., Kausar, F., Farooqi, M.A., Chethikkattuveli Salih, A.R., Hyun, K., Lim, J.H., Khalil, A.A.K., Mumtaz, A.S. and Choi, K.H., 2022. Study of the Anticancer Potential of Plant Extracts Using Liver Tumor Microphysiological System. Life, 12(2), p.135.
Bari, A., Shah, S.M.M., Al-Joufi, F.A., Shah, S.W.A., Shoaib, M., Shah, I., Zahoor, M., Ahmed, M.N., Ghias, M., Shah, S.M.H. and Khalil, A.A.K., 2022. Effects of Artemisia macrocephala Jacquem on Memory Deficits and Brain Oxidative Stress in Streptozotocin-Induced Diabetic Mice. Molecules, 27(8), p.2399.
Alharbi, M., Alshammari, A., Alasmari, A.F., Alharbi, S.M., Tahir ul Qamar, M., Ullah, A., Ahmad, S., Irfan, M. and Khalil, A.A.K., 2022. Designing of a Recombinant Multi-Epitopes Based Vaccine against Enterococcus mundtii Using Bioinformatics and Immunoinformatics Approaches. International journal of environmental research and public health, 19(6), p.3729.
Hussain, H., Ahmad, S., Shah, S.W.A., Ullah, A., Ali, N., Almehmadi, M., Ahmad, M., Khalil, A.A.K., Jamal, S.B., Ahmad, H. and Halawi, M., 2022. Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs. Molecules, 27(8), p.2468.

Department of Pharmacognosy

Pharmacognosy