Dr. Fakhar Un Nisa Yunus

Associate Professor (TTS)
Department of Zoology
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Profile
Research Publications

ACADEMIC QUALIFICATIONS
Qualifications and Institute		Post-Doc (SJTU, China) P.hD (PU) MSc (PU)

PROFESSIONAL EXPERIENCE
Joined LCWU since	2009

Work Experience	Serving as Tenured Associate Professor since 2020

HONORS AND AWARDS
1. Talented Young Scientist Fellowship, 2017-2019

GRANTS AND PROJECTS
1. NRPU-HEC project 2. Joint Project grant from Shanghai Government, China.

RESEARCH STUDENTS SUPERVISED
Title of Thesis	Year		Degree	Student Name
Synopsis in process	Supervisor 2022-2027		P.hD.	Sania Nawaz
Effect of site-directed mutagenesis of synergistically active Cry proteins against Spodoptera litura	Supervisor 2016-2024		P.hD.	Ms Huma Khurshid
Effect of random mutagenesis of synergistically active Cry proteins against Earias insulana & Earias vitella	Supervisor 2016-2024		P.hD.	Ms Hafsa Zaheer
Biocontrol activity of Bacillus thuringiensis Cry proteins against Asian Citrus psyllid (Diaphornia citri)	Co-Supervisor 2016-2024		P.hD.	Ayesha Butt
Total Number of Students			MS	40
Total Number of Students			BS	31

SELECTED PROFESSIONAL PRESENTATIONS

1. 1^st International conference & 3^rd International conference for cancer metabolism and therapy, 12^th-14^th, October 2018, Shanghai, China.

2. Poster presentation in 2^nd international conference for cancer metabolism and therapy on “Monoclonal antibody against protein disulphide isomerase AGR2 as a novel agent in suppressing tumor growth and metastasis” 13^th -15^th, October 2017, Wenzhou, China.

3. Poster presentation on “Mosquito: as a Biological Vector” in 2 days national conference on “Defeating the public enemy, the mosquito:a real challenge. 3-4^th December, 2014, Department of Zoology, Lahore College for Women University, Lahore

4. Poster presentation on “Antimicrobial activity of essential oils against soil isolates” 28^th -2^nd, March 2017. International 37^th Pakistan Congress of Zoology.

OTHER NOTE-WORTHY ACHIEVEMENTS

1. Awarded Talented Young Scientist Fellowship, Ministry of Science and Technology, Beijing, China.

2. Chinese patent for therapeutic monoclonal antibody 15D8A4 against lung cancer.

RESEARCH INTERESTS	Microbiology/Molecular Biology/Therapeutic Monoclonal antibody

Publications

1. Hafsa Zaheer, Huma Khurshid, Fakhar-un-Nisa Yunus^*, Farkhanda Manzoor, Ghazala Jabeen, Zakia Kanwal. (2023). Random mutagenesis to enhance the toxicity of Bacillus thuringiensis Cry proteins against Earias vitella (F.). Sains Malaysiana, 52(10): 3061-3072. (IF: 1.006).

2. Huma khurshid, Hafsa Zaheer, Fakhar-un-Nisa Yunus*, Farkhanda Manzoor, Asma Abdul Latif, Farzana Rashid. (2023). Site-directed mutagenesis in Cry proteins of Bacillus thuringiensis to demonstrate the role of domain II and domain III in toxicity enhancement towards Spodoptera litura. Egyptain Journal of Biological Pest Control, 33(86):1-9. (IF: 2.4).

3. Debmalya Roy, Guo-Song Liu, Wang Zeling, Bingjie Zhou, Fakhar-un-Nisa Yunus, Ghulam Raza, Siva Bharath Merugu, Dhahiri Saidi Mashausi, Dawei Li. 2023. Construction and stable expression of AGR2xPD1 bi-specific antibody that enhances attachment between T-cells and lung tumor cells, suppress tumor cell migration and promoting CD8 expression in cytotoxic T-cells. Journal of Saudi Pharmaceutical (IF: 4.30), 31(1): 85-95.

4. Iqra Noshair , Zakia Kanwal, Ghazala Jabeen, Mateen Arshad, Fakhar-Un-Nisa Yunus, Ramsha Hafeez, Rida Mairaj, Imran Haider, Naushad Ahmad and Suliman Yousef Alomar . 2023. Assessment of Dietary Supplementation of Lactobacillus rhamnosus Probiotic on Growth Performance and Disease Resistance in Oreochromis niloticus. Microorganisms (IF: 4.926) 11: 1423. https://doi.org/10.3390/microorganisms11061423

5. Dhahiri Saidi Mashausi, Debmalya Roy, Hitesh Bhagavanbhai Mangukiya, Siva Bharath Merugu, Ghulam Raza, Fakhar-Un-Nisa Yunus, Guo-Song Liu, Hema Negi, Dawei Li. 2022. A high efficient FVIII variant corrects bleeding in hemophilia A mouse model. Biochemical and Biophysical Research Communications (IF: 3.575), 637:358-364

6. Siva Bharath Merugu, Bingjie Zhou, Hitesh Bhagavanbhai Mangukiya, Hema Negi, Raza Ghulam, Debmalya Roy, Sehar Qudsia, Zeling Wang, Dhahiri Saidi Mashausi, Fakhar-Un-Nisa Yunus, Guo-Song Liu, Dawei Li. 2021. Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to β-catenin that requires AGR2 dimerization and adhesion domains. Biochemical and Biophysical Research Communications, 573:82-92, (IF: 3.575).

7. Ghulam Raza, Fakhar-un-Nisa Yunus^*, Hitesh Bhagavanbhai Mangukiya, Siva Bharath Merugu, Dhahiri Saidi Mashausi, Wang Zeling, Hema Negi, Bingjie Zhou, Debmalya Roy, Zhenghua Wu , Dawei Li. 2021. A novel target anti-interleukin-13 receptor subunit alpha-2 monoclonal antibody inhibits tumor growth and metastasis in lung cancer. International Immunopharmacology, (IF: 4.932).

8. Debmalya Roy, Ipshita Khanra, Wang Zeling, Siva Bharath Merugu, Fakhar-un-Nisa Yunus, Dhahiri Saidi Mashausi, Dawei Li. 2020. Emerging Novel Coronavirus is a Global Threat: Insight in the Biology of COVID-19 and its Hijacking Process of Hosts’ Cell. Current Pharmaceutical Design, 26: 1. (IF: 2.575)

9. Hema Negi, Siva Bharath Merugu, Hitesh Bhagavanbhai Mangukiya, Zheqi Lib, Bingjie Zhou, Qudsia Sehar, Suchitra Kamle, Fakhar-un-Nisa Yunus, Dhahiri Saidi Mashausi,Zhenghua Wu, Dawei Li. 2019. Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study. Cancer Letters. 449: 125–134 (IF: 6.491).

10. Bingjie Zhou, Hitesh Bhagavanbhai Mangukiya, Yuchen Fan, Fakhar-un-Nisa Yunus, Siva Bharath Merugu, Zhenghua Wu, Dawei Li. 2019. Cloning, expression, purification and characterization of soluble bioactive recombinant human anterior gradient homolog 2-DsRed monomer protein in E. coli. Pakistan Journal of Zoology, (IF: 0.7).

11. Fakhar-un-Nisa Yunus, Ghulam Raza, Rahat Makhdoom, Hafsa Zaheer. 2019. Genetic improvement of Bacillus thuringiensis against the cotton bollworm, Earias vitella (Fab.) (Lepidoptera: Noctuidae) to improve the cotton yield in Pakistan. Egyptain Journal of Biological Pest Control, (IF: 0.381).

12. Hitesh Mangukiya, Hema Negi, Siva Merugu, Qudsia Sehar, Fakhar-un-Nisa Yunus, Zhenghua Wu, and Dawei Li. 2019. Paracrine signaling of AGR2 activates RhoA in fibroblasts and modulates cell elongation, migration and organization. Journal of Cell adhesion and Migration, 13(1):332–344 (IF: 3.5).

13. Arooj Ahsan, Muhammad Naeem Iqbal, Asfa Ashraf, Fakhar-un-Nisa Yunus, Mirza Imran Shahzad, Mehwish Saleem. 2020. Risk Factors Associated with Pulmonary Tuberculosis among Health Care Workers of Mayo Hospital, Lahore, Pakistan. PSM Microbiology, 5(3): 033.

14. Muhammad Naeem Iqbal*, Asfa Ashraf, Iqra Iqbal, Azara Iqbal, Saman Alam, Fakhar-un-Nisa Yunus. 2018. Incidence of Hypertension among Various Age Groups in Narowal, Pakistan. International Journal of Nanotechnology and Allied Sciences; 2(2):12-15.

15. Sehrish Akram, Shakil Ahmad Khan, Fakhar- un- Nisa, Mubashar Hussain*, Maimoona Kanwal, Fatima Zafar. 2017. Impact of Cholecalciferol (D3) supplementation on biology and cocoon yield of silkworm, Bombyx mori L. Asian Journal of Agriculture & Biology, 5(4):214-220.

16. Fakhar-un-Nisa Yunus, Hira Saeed, Farzana Rashid, Muhammad Naeem Iqbal, Asfa Ashraf. 2017. Isolation and Identification of Esterase Producing Bacillus subtilis from Soil. PSM Microbiology, 2 (2): 24-28.

17. Muhammad Kalim, Muhammad Imran, Firasat Hussain, Inam Ullah Khan, Neeli Habib, Muhammad Naeem Iqbal, Asfa Ashraf, Fakhar-Un-Nisa Yunus. 2016. Prevalence of HBV and HCV by ICT and ELISA Method in Different Areas of District Malakand. A peer-reviewed open access Journal PSM Medical Research, 1(1): 01-05.

18. Muhammad Naeem Iqbal*, Asfa Ashraf, Fakhar-un-Nisa Yunus, Ali Muhammad, Saman Alam, Shiwei Xiao, Shahzad Ali, Muhammad Irfan. 2016. Prevalence of Angina Pectoris in Relation to Various Risk Factors. A peer-reviewed open access Journal PSM Vetrinary Research, 1(1): 06-10.

19. Saman Alam, Saima Masood, Muhammad Naeem Iqbal, Asfa Ashraf, Fakhar-un-Nisa Yunus, Shiwei Xiao, Misbah Ahsan. 2016. Effect of Sodium Selenite on Kidney Function Test of Rabbits. A peer-reviewed open access Journal PSM Veterinary Research, 1(1): 17-21.

20. Farzana Rashid, Fatima Amjad Butt, Sobia Nasreen, Fakhr un nisa, Zakia kanwal, Afshan kaleem and Syeda Andleeb. 2016. In vitro antimicrobial and antioxidant activities of two medicinal plants against some clinically important bacteria. FUUAST J. BIOL., 6(1): 103-107.

21. Fakhar-un-Nisa Yunus, Faiza Kanwal, Farzana Rashid, Asfa Ashraf, Muhammad Naeem Iqbal*. 2016. A Comparative Study on Isolation and Identification of Bacillus thuringiensis from Different Localities of Gujranwala City. A peer-reviewed open access Journal PSM Biological Research, 1(1): 34-38.

22. Fakhar-un-Nisa Yunus, Madiha Iqbal, Khajista Jabeen, Zakia Kanwal, Farzana Rashid. 2016. Antagonistic activity of pseudomonas fluorescens against fungal plant pathogen Aspergillus niger. Science Letters, 4 (1): 66-70.

23. Muhammad Naeem Iqbal, Aftab Ahmad Anjum, Shihua Wang, Muhammad Asad Ali, Asfa Ashraf, FN Yunus, S Ali, A Muhammad, MI Shahzad. 2016. A Mini Review on Microbiological Quality of Commercial Fruit Juices in Pakistan. PSM Microbiology, 1(1): 26-32.

24. Fakhar-un-Nisa Yunus, Muhammad Nadeem, and Farzana Rashid. 2015. Single cell protein production through microbial conversion of lignocellulosic residue (wheat bran) for animal feed. Journal of the Institute of Brewing, 121 (4): 553-557. (IF: 1.24).

25. Afshan Kaleem, Farhana Munir, Mehwish Iqtedar, Roheena Abdullah, Fakhar-un-Nisa, Irfana Iqbal, Faiza Saleem, Mahwish Aftab and Shagufta Naz. 2015. Genetic analysis of gene responsive to tuberculosis in under developing areas of Pakistan. Journal of Pure and Applied microbiology, Vol. 9(Spl. Edn. 1): 319-324. (IF: 0.073).

26. Mehwish Iqtedar, Uzma Sarwar, Roheena Abdullah,Afshan Kaleem, Mahwish Aftab, Shagufta Naz, Fakhar-un Nisa, Saima Sharif, Saima Aftab and Shagufta Naz. 2015. Increasing Shelf Life of Pakistani Peaches Using Gamma Irradiation to Overcome Quarantine Barriers in Fruit Exports From Pakistan. Journal of Pure and Applied microbiology, Vol. 9(Spl. Edn. 1): 313-318. (IF: 0.073).

27. Fakhar-un-Nisa Yunus, Muhammad Nadeem, Farzana Rashid. 2015. Enhancement of protein contents of rice bran for animal feed by solid state fermentation. Biomedical Letters, I (1): 31-36 (Indexed).

28. Fakhar-un-Nisa Yunus, Khadija Asif, Farzana Rashid. 2015. Oviposition behavior of pulse beetle Callosobruchus chinensis (L) reared on different pulses and cereals. Biomedical Letters, I (1): 5-8 (Indexed).

29. Farzana Rashid, Nadia Sharif, Ijaz Ali, Shagufta Naz, Saima Sharif and Fakhar - un – Nisa. 2013. Antimicrobial potential of Lactococcus lactis bacteriocin against Salmonella typhi. African Journal of Microbiology Research, 7(6):436-439 (IF: 0.564).

30. Farzana Rashid, Nadia Sharif, Ijaz Ali, Saima Sharif, Fakhar Un Nisa and Shagufta Naz. 2013. Phytochemical analysis and inhibitory activity of Ornamental Plant (Bougainvillea spectabilis). Asian Journal of Plant Science and Research, 3(2):1-5, (Indexed).

31. Kausar Malik, Ferhana Munir, Khansa, Fakhar-un-Nisa, Shagufta Naz, Saima Sharif Farzana Rashid and Khadija Awan. 2012. Biotoxicity assay of Bacillus thuringiensis (Spores) against Tribolium castaneum. African Journal of Microbiology Research, 6(18):3980-3983, (IF: 0.564).

32. Kausar Malik, Khalid Pervaiz Lone, Khansa, Farzana Rashid, Fakhar-un-Nisa, Shagufta Naz, Saima Sharif and Khadija Awan. 2012. Effect of feeding rapeseed meal on the liver weight and hepato-somatic index (HIS) content of liver of Japanese quail. African Journal of Microbiology Research, 6(9):1918-1923 (IF: 0.564).

33. Fakhar-un-Nisa yunus, Kausar Malik, Ghulam raza, Rahat makhdoom. 2011. Additive effect of neem (Azadirachta indica) with Bacillus thuringiensis Cry protein. International Journal of Cell & Molecular Biology, 2 (2):576-579 (IF: 1.94).

34. Fakhar-un-Nisa yunus, Rahat makhdoom, Ghulam raza. 2011. Synergism between Bacillus thuringiensis toxins Cry1Ac and Cry2A against Earias vitella. Pakistan journal of Zoology, 43(3), 575-580 (IF: 0.7).

35. Tasnim Farasat, Tahira Mughal, Aiyesha Bilal, Fakhar-un-Nisa. 2010. Isolation and biochemical identification of E. coli from waste effluents of a dairy industry. J App Pharm., 3(2): 86-88 (IF: 0.44).

36. Ghulam Raza,Khalil-ur-Rehman,Munir A. Sheikh and Fakhar-un-Nisa. 2009. Production of Rabbit Antibovine Antibodies-Horse Radish Peroxidase conjugate (Ab/HRPO) using Periodate Oxidation Method. Science International, 21(3):165-168 (Indexed).

37. Maryam yunus, Tehmina, Tayyab Husnain, Fakhar-un-Nisa. 2008. Baseline susceptibility of red flour beetle (Tribolium castaeum Herbst) to Bacillus thuringiensis toxins. Journal of Sustainable agriculture, 32(1):181-190 (IF: 0.3).

38. Fakhar-un-Nisa, Fauzia Qamar, Firdousia Azam Ali. 2005. Biochemical analysis of Callosubrochus chinensis reared on different diets. Sci. Int., 17(4), 309-312 (Indexed).

BOOKS AND CHAPTERS PUBLISHED

1. Asma Abdul Latif, Fakhar-un-Nisa Yunus, Zakia Kanwal, Saffora Riaz. 2023. The nutritional benefits of Moringa oleifera: In: Complementary and Alternative Medicine: One Health Perspective (Sindhu ZuD, B Aslam, U Uslu & M Mohsin, eds): 2023/ FahumSci, Lahore, Pakistan, pp: 199-203. ISBN: 978-627-7745-01-1. https://doi.org/10.61748/CAM.2023/027.

Department of Zoology

Zoology